Zulfiqar Ali Bhutto married Nusrat Isphahani on September 8, 1951.His first child, Benazir Bhutto, was born on June 21. On his return to Pakistan, Bhutto started practicing Law at Dingomal’s.
In 1958, he joined President Iskander Mirza’s Cabinet as Commerce Minister. He was the youngest Minister in Ayub Khans Cabinet. In 1963, he took over the post of Foreign Minister from Muhammad Ali Bogra. His first major achievement was to conclude the Sino-Pakistan boundary agreement on March 2, 1963. In mid 1964, Bhutto helped convince Ayub of the wisdom of establishing closer economic and diplomatic links with Turkey and Iran. The trio later on formed the R. C. D. In June 1966, Bhutto left Ayub’s Cabinet over differences concerning the Tashkent Agreement.
Zulfiqar Ali Bhutto launched Pakistan Peoples Party after leaving Ayub’s Cabinet. In the general elections held in December 1970, P. P. P. won a large majority in West Pakistan but failed to reach an agreement with Sheikh Mujib-ur-Rahman, the majority winner from East Pakistan. Following the 1971 War and the separation of East Pakistan, Yahya Khan resigned and Bhutto took over as President and Chief Martial Law Administrator on December 20, 1971.
In early 1972, Bhutto nationalized ten categories of major industries, and withdrew Pakistan from the Commonwealth of Nations and S. E. A. T. O. when Britain and other western countries recognized the new state of Bangladesh. On March 1, he introduced land reforms, and on July 2, 1972, signed the Simla Agreement with India, which paved the way for the return of occupied lands and the release of Pakistani prisoners captured in East Pakistan in the 1971 war.
After the National Assembly passed the 1973 Constitution, Bhutto was sworn-in as the Prime Minister of the country.
On December 30, 1973, Bhutto laid the foundation of Pakistan’s first steel mill at Pipri, near Karachi. On January 1, 1974, Bhutto nationalized all banks. On February 22, 1974, the second Islamic Summit was inaugurated in Lahore. Heads of States of most of the 38 Islamic countries attended the Summit.
Following a political crisis in the country, Bhutto was imprisoned by General Zia-ul-Haq, who imposed Martial Law on July 5, 1977.
On April 4, 1979, the former Prime Minister was hanged, after the Supreme Court upheld the death sentence passed by the Lahore High Court. The High Court had given him the death sentence on charges of murder of the father of a dissident P. P. P. politician.He was buried in his ancestral village at Garhi Khuda Baksh, next to his father’s grave.
Another respectful title commonly bestowed upon him by supporters is Quaid-e-Awam, or "Leader of the Masses" as he was indeed a populist statesman.